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While in peptide 20 bound to GCGR, the γ-carboxylate spacer contributed the same hydrogen bonds (with S139 1.37 , Q142 1.40 and K202 2.75 ) as MEDI0382, but the 16-carbon palmitic chain terminus swayed to TM2 rather than dropped down along TM1, thus making different hydrophobic contacts with L192 2.65 and V193 2.66 , as well as a hydrogen bond with R199 2.72 (Fig
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