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It supports: Impurity profiling at extremely low abundance Structural verification via peptide mapping and top-down or middle-down analysis Disulfide bond and post-translational modifications (PTMs) characterization, which influence folding and bioactivity Isomer differentiation, critical in D/L variants that evade traditional detection MS is also essential in bridging innovation and access
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The authors concluded: “Further research is needed to determine if there is a true cause and effect relationship in the association identified in this investigation and to understand the trade-offs between the benefits and risks of GLP-1 RAs.” Also in June, the European Medicines Agency safety committee warned that semaglutide (active substance in Ozempic, Rybelsus and Wegovy) may cause the NAION optic neuropathy described earlier in this article
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